TPM4 (tropomyosin )
نویسندگان
چکیده
منابع مشابه
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia
Platelets are anuclear cells that are essential for blood clotting. They are produced by large polyploid precursor cells called megakaryocytes. Previous genome-wide association studies in nearly 70,000 individuals indicated that single nucleotide variants (SNVs) in the gene encoding the actin cytoskeletal regulator tropomyosin 4 (TPM4) exert an effect on the count and volume of platelets. Plate...
متن کاملTropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells
An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells. The antibody produces a fluorescent pattern which is very similar to that obtained with an actin-specific antibody. This pattern is composed of fluorescent fibers which are shown to be coincident with the fibers see...
متن کاملTropomyosin keeps actin tough
Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...
متن کاملCaldesmon-binding sites on tropomyosin.
The interaction of chicken gizzard caldesmon with fragments of tropomyosin, generated by chemical, enzymatic, and mutational means, was studied to determine the caldesmon-binding site(s) on tropomyosin. Binding was examined by fluorescence spectroscopy and affinity chromatography. Removal of residues 1-141 and 228-284, respectively, from the NH2 and COOH ends of tropomyosin did not affect its b...
متن کاملActin Dynamics: Tropomyosin Provides Stability
Tropomyosin stabilizes actin filaments, while ADF/cofilin promotes their disassembly. These two proteins compete with each other for binding to the actin filament, providing a critical balance for actin assembly in vivo.
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37785